2-Methyl-2-thiopseudourea sulfate → Guanidine Sulfate (1:1)

HRID 65949

Reaction equation

HRID 65949 reaction equation
CC1[N:3]=[CH:4][NH:5]C=1CSCCN.[S:12]([OH:16])([OH:15])(=[O:14])=[O:13].CSC(=N)[NH2:20]>O>[S:12]([OH:16])([OH:15])(=[O:14])=[O:13].[NH2:3][C:4]([NH2:5])=[NH:20]

Participants

4

Reactant 2

HCID 752702-Methyl-2-thiopseudourea sulfateHCID 178433288HCID 178433288, compound

Product 1

HCID 499987Guanidine Sulfate (1:1)Yield 103.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 4-methyl-5-((2-aminoethyl)thiomethyl)imidazole (19.0 g.) and S-methylisothiourea sulphate (15.1 g.) in water (100 ml.) was heated under reflux for 3 hours. Concentration, acidification with sulphuric acid and dilution with ethanol afforded 2-[(4-methyl-5-imidazolyl)methylthio)ethyl]guanidine sulphate (13.0 g.) m.p. 230°-235° (from aqueous methanol).

Workup

  1. temperatureunder reflux for 3 hours
  2. concentrationConcentration, acidification with sulphuric acid and dilution with ethanol

Sources & evidence

ORD record
ord-d142530121634bff9dac22d3af7bde46
Source dataset
uspto-grants-1978_12
Patent number
US04129657

Linked notes

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