Potassium tert-butoxide → HCID 68838475, compound
Reaction equation
[NH2:1][S:2]([N:5]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19](=[O:27])[O:20][CH2:21][CH2:22][Si:23]([CH3:26])([CH3:25])[CH3:24])=[CH:13][C:12]=1[O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:6][C:7](OC)=[O:8])(=[O:4])=[O:3].CC(C)([O-])C.[K+]>C1COCC1>[CH3:24][Si:23]([CH3:26])([CH3:25])[CH2:22][CH2:21][O:20][C:19](=[O:27])[CH2:18][O:17][C:14]1[CH:15]=[CH:16][C:11]([N:5]2[CH2:6][C:7](=[O:8])[NH:1][S:2]2(=[O:4])=[O:3])=[C:12]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:13]=1Participants
4
Procedure
To a solution of methyl N-(aminosulfonyl)-N-(2-(benzyloxy)-4-{2-oxo-2-[2-(trimethylsilyl)ethoxy]ethoxy}phenyl)glycinate in THF is added potassium t-butoxide (1.1 equivalent) in THF dropwise. The mixture is stirred at RT for 18 h. The solvent is removed under reduced pressure to afford the title compound which is used directly in the next step.