4-Toluenesulfonyl chloride → 3-[2-(4-p-Toluenesulphonamido-1-piperidyl)ethyl]indole

HRID 66304

Reaction equation

HRID 66304 reaction equation
O.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[NH:13][CH:12]=2)[CH2:5][CH2:4]1.[C:20]1([CH3:30])[CH:25]=[CH:24][C:23]([S:26](Cl)(=[O:28])=[O:27])=[CH:22][CH:21]=1>>[C:20]1([CH3:30])[CH:25]=[CH:24][C:23]([S:26]([NH:2][CH:3]2[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[NH:13][CH:12]=3)[CH2:5][CH2:4]2)(=[O:28])=[O:27])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 203843533-[2-(4-Aminopiperidyl)ethyl]indole, hydrate

Product 1

HCID 227548423-[2-(4-p-Toluenesulphonamido-1-piperidyl)ethyl]indole

Procedure

Using an analogous procedure to Example 1 3[2-(4-amino-1-piperidyl)ethyl]indole monohydrate may be reacted with p-toluenesulphonyl chloride to give the title compound.

Sources & evidence

ORD record
ord-2d3d020eed65469c976f193f30c90ee8
Source dataset
uspto-grants-1978_12
Patent number
US04131680

Linked notes

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