Dabco → Benzene-1,2-disulfonamide
Reaction equation
NC1N=[C:6]([CH3:8])[C:5](C)=[C:4](C)N=1.[S:11]([N:17]=C=O)(N=C=O)(=[O:13])=[O:12].C1N2[CH2:26][CH2:27]N(CC2)C1>C(#N)C>[C:4]1([S:11]([NH2:17])(=[O:13])=[O:12])[C:5]([S:11]([NH2:17])(=[O:13])=[O:12])=[CH:6][CH:8]=[CH:26][CH:27]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 0.8 g of 2-amino-4,5,6-trimethylpyrimidine, 2.8 g of the crude sulfonyl isocyanate from Example 9 and a few crystals of DABCO in 25 ml of acetonitrile is stirred at room temperature for 16 hours. A small amount of unreacted aminopyrimidine is filtered off and the filtrate concentrated in-vacuo to give a hard glass. Crystallization from methanol gives N,N-diethyl-N'[4,5,6-trimethylpyrimidin-2-yl)aminocarbonyl]-1,2-benzenedisulfonamide as a white solid.
Workup
- filtrationA small amount of unreacted aminopyrimidine is filtered off
- concentrationthe filtrate concentrated in-vacuo
- customto give a hard glass
- customCrystallization from methanol
Sources & evidence
- ORD record
- ord-1444c1eac8794057a4dcdddb36f4a749
- Source dataset
- uspto-grants-1982_08
- Patent number
- US04342587
Reaction notes
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