2-Chloro-6-hydroxybenzaldehyde → 5-Chloro-1-benzofuran-2-carboxylic acid

HRID 66599

Reaction equation

HRID 66599 reaction equation
[Cl:1]C1C=CC=C(O)C=1C=O.F[C:12]1[CH:23]=[CH:22][C:15]2[O:16][C:17]([C:19]([OH:21])=[O:20])=[CH:18][C:14]=2[CH:13]=1.ClC1C=CC2C=C(C(O)=O)OC=2C=1>>[Cl:1][C:12]1[CH:23]=[CH:22][C:15]2[O:16][C:17]([C:19]([OH:21])=[O:20])=[CH:18][C:14]=2[CH:13]=1

Participants

4

Reactant 3

HCID 5283932-Chloro-6-hydroxybenzaldehydeHCID 109868725-Fluoro-1-benzofuran-2-carboxylic acidHCID 137487046-Chloro-1-benzofuran-2-carboxylic acid

Product 1

HCID 9378385-Chloro-1-benzofuran-2-carboxylic acid

Procedure

By the same procedure, 5-fluorosalicyaldehyde and 6-chlorosalicylaldehyde are converted, respectively, to 5-fluorobenzo[b]furan-2-carboxylic acid and 6-chlorobenzo[b]furan-2-carboxylic acid.

Sources & evidence

ORD record
ord-9d6d6bcbf28a46838f85a3693706725c
Source dataset
uspto-grants-1982_08
Patent number
US04342771

Linked notes

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