Methyl acetoacetate → HCID 178429333, compound
Reaction equation
[Cl:1][C:2]([Cl:7])([Cl:6])[C:3]([NH2:5])=[NH:4].C[O:9][C:10](=O)[CH2:11][C:12]([CH3:14])=O.C(=O)([O-])[O-].[K+].[K+]>O>[OH:9][C:10]1[CH:11]=[C:12]([CH3:14])[N:5]=[C:3]([C:2]([Cl:7])([Cl:6])[Cl:1])[N:4]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 44.4 g (0.28 mole) trichloroacetamidine, 32.0 g (0.28 mole) methylacetoacetate, 37.5 g (0.28 mole) potassium carbonate, and 450 ml water was stirred for 3 days. A trace of solid was removed by filtration and the filtrate was made acidic with hydrochloric acid. The product precipitated out to give 28.9 g (46% yield; mp 173°-174° C.). The structure was confirmed via mp*, infrared and elemental analysis.
Workup
- customA trace of solid was removed by filtration
- customThe product precipitated out
- customto give 28.9 g (46% yield; mp 173°-174° C.)
Sources & evidence
- ORD record
- ord-71fc33f291614c5e91f54f39326cf623
- Source dataset
- uspto-grants-1982_08
- Patent number
- US04343803
Reaction notes
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