Methanol → 2-Amino-5-bromo-3-methoxypyrazine
Reaction equation
[NH2:1][C:2]1[C:7](Br)=[N:6][C:5]([Br:9])=[CH:4][N:3]=1.[Na].[CH3:11][OH:12]>>[NH2:1][C:2]1[C:7]([O:12][CH3:11])=[N:6][C:5]([Br:9])=[CH:4][N:3]=1Participants
4
Procedure
2-Amino-3,5-dibromopyrazine (7 g.) is boiled for about 9 hours with 0.65 g. sodium in 18.5 ml. methanol to give 2-amino-3-methoxy-5-bromopyrazine.
Sources & evidence
- ORD record
- ord-c734855d3b894e15aec42e003dc98bdd
- Source dataset
- uspto-grants-1982_08
- Patent number
- US04343802
Reaction notes
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