Acetic Acid → 2-(6-(Pyrrolidin-1-ylmethyl)thiazolo[5,4-b]pyridin-2-yl)aniline

Reaction equation

[C:29](=[O:30])([O-:31])[O-:32].[CH3:25][C:26](=[O:27])[OH:28].[Cl:35][CH2:36][Cl:37].[Fe:38].[N+:1]([O-:2])(=[O:3])[c:4]1[c:5](-[c:10]2[s:11][c:12]3[n:13][cH:14][c:15]([CH2:19][N:20]4[CH2:21][CH2:22][CH2:23][CH2:24]4)[cH:16][c:17]3[n:18]2)[cH:6][cH:7][cH:8][cH:9]1.[Na+:33].[Na+:34]>>[NH2:1][c:4]1[c:5](-[c:10]2[s:11][c:12]3[n:13][cH:14][c:15]([CH2:19][N:20]4[CH2:21][CH2:22][CH2:23][CH2:24]4)[cH:16][c:17]3[n:18]2)[cH:6][cH:7][cH:8][cH:9]1

Participants

Reactant 6

HCID 176Acetic Acid

HCID 923Sodium Ion2×

HCID 6344Dichloromethane

HCID 19660Carbonate Ion

HCID 23925Iron

HCID 585518892-(2-Nitrophenyl)-6-(pyrrolidin-1-ylmethyl)thiazolo[5,4-b]pyridine

Product 1

HCID 585518882-(6-(Pyrrolidin-1-ylmethyl)thiazolo[5,4-b]pyridin-2-yl)aniline

Sources & evidence

ORD record: ord-90bd871194524a3fb35d22e78ff96404
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…