Acetaldehyde → Quindoxin

HRID 66953

Reaction equation

HRID 66953 reaction equation
[CH:1]1[CH:9]=[CH:8][C:7]2[C:3](=[N:4][O:5][N+:6]=2[O-:10])[CH:2]=1.[CH:11](=O)[CH3:12]>C(N(CC)CC)C>[CH:9]1[CH:8]=[C:7]2[N:6]([O-:10])[CH:11]=[CH:12][N+:4](=[O:5])[C:3]2=[CH:2][CH:1]=1

Participants

4

Reactant 2

HCID 177AcetaldehydeHCID 68075Benzofuroxan

Product 1

HCID 72073Quindoxin

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A mixture of benzofuroxan (2.5 g.), acetaldehyde (2.5 ml.) and triethylamine (20 ml.) is allowed to stand at room temperature for 24 hours. The solid material which precipitates is filtered and dried to give product, M.P. 223°-224° C. dec. (MIC against P. vulgaris is 12.5 mcg./ml.).

Workup

  1. customThe solid material which precipitates
  2. filtrationis filtered
  3. customdried
  4. customto give product, M.P. 223°-224° C. dec. (MIC against P. vulgaris is 12.5 mcg./ml.)

Sources & evidence

ORD record
ord-9a9924cf8a364a74964e4f5b2ea9c2dc
Source dataset
uspto-grants-1982_08
Patent number
US04343942

Linked notes

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