Tetrahydrofuran → 8-(1-Ethyl-propyl)-2,6-dimethyl-3-(2-methyl-thieno[3,2-c]pyridin-3-yl)-imidazo[1,2-b]pyridazine

Reaction equation

[Br:1][c:2]1[c:3]([CH3:11])[s:4][c:5]2[c:6]1[cH:7][n:8][cH:9][cH:10]2.[CH2:12]([CH3:13])[CH:14]([CH2:15][CH3:16])[c:17]1[c:18]2[n:19]([n:20][c:21]([CH3:23])[cH:22]1)[c:24]([I:28])[c:25]([CH3:27])[n:26]2.[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[Zn:34]>>[c:2]1(-[c:24]2[n:19]3[c:18]([c:17]([CH:14]([CH2:12][CH3:13])[CH2:15][CH3:16])[cH:22][c:21]([CH3:23])[n:20]3)[n:26][c:25]2[CH3:27])[c:3]([CH3:11])[s:4][c:5]2[c:6]1[cH:7][n:8][cH:9][cH:10]2

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 23994Zinc

HCID 577526818-(1-Ethyl-propyl)-3-iodo-2,6-dimethyl-imidazo[1,2-b]pyridazine

HCID 688565793-Bromo-2-methyl-thieno[3,2-c]pyridine

Product 1

HCID 577526268-(1-Ethyl-propyl)-2,6-dimethyl-3-(2-methyl-thieno[3,2-c]pyridin-3-yl)-imidazo[1,2-b]pyridazine

Sources & evidence

ORD record: ord-6e90aa588ccc4b34882dd36000fa36d0
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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