1,2-Dichloroethane → N-(1-acetyl-2,3-dihydroindol-6-yl)-N-(1-benzylpiperidin-3-yl)-3-phenylprop-2-enamide

HRID 677054

Reaction equation

HRID 677054 reaction equation
[C:41]([N:42]1[c:43]2[c:44]([cH:45][cH:46][c:47]([NH2:48])[cH:49]2)[CH2:50][CH2:51]1)(=[O:52])[CH3:53].[C:54]([OH:55])(=[O:56])[CH3:57].[C:58]([CH:59]=[CH:60][c:61]1[cH:62][cH:63][cH:64][cH:65][cH:66]1)(=[O:67])[Cl:68].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([NH:14][c:15]2[cH:16][cH:17][c:18]3[c:22]([cH:23]2)[N:21]([C:24]([CH3:25])=[O:26])[CH2:20][CH2:19]3)[CH2:11][CH2:12][CH2:13]1.[CH2:27]([N:28]1[CH2:29][CH2:30][CH2:31][C:32](=[O:33])[CH2:34]1)[c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1.[Cl:69][CH2:70][CH2:71][Cl:72]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([N:14]([c:15]2[cH:16][cH:17][c:18]3[c:22]([cH:23]2)[N:21]([C:24]([CH3:25])=[O:26])[CH2:20][CH2:19]3)[C:58]([CH:59]=[CH:60][c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)=[O:67])[CH2:11][CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 176Acetic AcidHCID 660233-Phenylprop-2-enoyl chlorideHCID 966503-Piperidinone, 1-(phenylmethyl)-HCID 2585641-Acetyl-6-aminoindolineHCID 692108951-[6-(1-Benzyl-piperidin-3-ylamino)-2,3-dihydro-indol-1-yl]-ethanone

Product 1

HCID 69209232N-(1-acetyl-2,3-dihydroindol-6-yl)-N-(1-benzylpiperidin-3-yl)-3-phenylprop-2-enamide

Sources & evidence

ORD record
ord-e2289c11ad7245a695baaf1b4e9370bf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Linked notes

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