Tetrahydrofuran → N-{4-[6-Cyano-7-(2-hydroxy-(3-morpholin-4-yl)propoxy)quinolin-4-yloxy]-2-fluorophenyl}-N'-(4-fluorophenyl)urea

Reaction equation

[C:7](#[N:8])[c:9]1[cH:10][c:11]2[c:12]([O:24][c:25]3[cH:26][c:27]([F:42])[c:28]([NH:31][C:32](=[O:33])[NH:34][c:35]4[cH:36][cH:37][c:38]([F:41])[cH:39][cH:40]4)[cH:29][cH:30]3)[cH:13][cH:14][n:15][c:16]2[cH:17][c:18]1[O:19][CH2:20][CH:21]1[O:22][CH2:23]1.[CH2:1]1[CH2:2][O:3][CH2:4][CH2:5][NH:6]1.[O:43]1[CH2:44][CH2:45][CH2:46][CH2:47]1>>[CH2:1]1[CH2:2][O:3][CH2:4][CH2:5][N:6]1[CH2:23][CH:21]([CH2:20][O:19][c:18]1[c:9]([C:7]#[N:8])[cH:10][c:11]2[c:12]([O:24][c:25]3[cH:26][c:27]([F:42])[c:28]([NH:31][C:32](=[O:33])[NH:34][c:35]4[cH:36][cH:37][c:38]([F:41])[cH:39][cH:40]4)[cH:29][cH:30]3)[cH:13][cH:14][n:15][c:16]2[cH:17]1)[OH:22]