Acetic Acid → Tert-butyl 4-cyclobutylpiperazine-1-carboxylate

HRID 678096

Reaction equation

HRID 678096 reaction equation
[C:1]1(=[O:5])[CH2:2][CH2:3][CH2:4]1.[C:23]([BH3-:24])#[N:25].[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH3:6][C:7](=[O:8])[OH:9].[N:10]1([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1.[Na+:26].[OH2:32]>>[CH:1]1([N:13]2[CH2:12][CH2:11][N:10]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:15][CH2:14]2)[CH2:2][CH2:3][CH2:4]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 923Sodium ionHCID 962WaterHCID 8028TetrahydrofuranHCID 14496CyclobutanoneHCID 143452tert-Butyl piperazine-1-carboxylateHCID 498716Cyano-borohydride

Product 1

HCID 57423951Tert-butyl 4-cyclobutylpiperazine-1-carboxylate

Sources & evidence

ORD record
ord-e3b6741537d64629b770df7423162097
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Linked notes

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