Dimethylamine → (6-Chloro-3-dimethylaminomethyl-isoquinolin-5-yl)-acetic acid methyl ester

Reaction equation

[CH2:22]1[O:23][CH2:24][CH2:25][CH2:26]1.[CH3:19][NH:20][CH3:21].[CH3:1][O:2][C:3]([CH2:4][c:5]1[c:6]2[cH:7][c:8]([CH2:16][Br:17])[n:9][cH:10][c:11]2[cH:12][cH:13][c:14]1[Cl:15])=[O:18]>>[CH3:1][O:2][C:3]([CH2:4][c:5]1[c:6]2[cH:7][c:8]([CH2:16][N:20]([CH3:19])[CH3:21])[n:9][cH:10][c:11]2[cH:12][cH:13][c:14]1[Cl:15])=[O:18]

Participants

Reactant 3

HCID 674Dimethylamine

HCID 8028Tetrahydrofuran

HCID 66880745(3-Bromomethyl-6-chloro-isoquinolin-5-yl)-acetic acid methyl ester

Product 1

HCID 66882460(6-Chloro-3-dimethylaminomethyl-isoquinolin-5-yl)-acetic acid methyl ester

Sources & evidence

ORD record: ord-32a8177c56c0452fa6780bd3b6644a77
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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