Dichloromethane → 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(3-methylthiopropoxy)quinazoline

HRID 680386

Reaction equation

HRID 680386 reaction equation
[Br:25][c:26]1[cH:27][c:28]([F:46])[c:29]([NH:30][c:31]2[n:32][cH:33][n:34][c:35]3[cH:36][c:37]([OH:43])[c:38]([O:41][CH3:42])[cH:39][c:40]23)[cH:44][cH:45]1.[CH2:47]([P:48]([CH2:49][CH2:50][CH2:51][CH3:52])[CH2:53][CH2:54][CH2:55][CH3:56])[CH2:57][CH2:58][CH3:59].[CH2:60]([Cl:61])[Cl:62].[CH3:19][S:20][CH2:21][CH2:22][CH2:23][OH:24].[N:1]([C:2]([N:3]1[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1)=[O:9])=[N:10][C:11]([N:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1)=[O:18]>>[CH3:19][S:20][CH2:21][CH2:22][CH2:23][O:24][c:37]1[cH:36][c:35]2[n:34][cH:33][n:32][c:31]([NH:30][c:29]3[c:28]([F:46])[cH:27][c:26]([Br:25])[cH:45][cH:44]3)[c:40]2[cH:39][c:38]1[O:41][CH3:42]

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 104483-(Methylthio)-1-propanolHCID 13831TributylphosphineHCID 730421,1'-(Azodicarbonyl)dipiperidineHCID 1355038524-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-quinazolinol

Product 1

HCID 224782814-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(3-methylthiopropoxy)quinazoline

Sources & evidence

ORD record
ord-e34880d30c584526a7dd3d767f4efd5e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Linked notes

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