Magnesium Stearate → Naloxone Fentanyl

HRID 68194

Reaction equation

[CH3:1][CH2:2][C:3]([N:5]([CH:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4].[CH2:26]([C:30](O)([C:35]([OH:37])=O)[CH2:31][C:32]([OH:34])=O)[C:27]([OH:29])=O.[C:39]([O-])(=O)[CH2:40]CCCCCCCCCCCCCCCC.[Mg+2].C([O-])(=[O:78])CCCCCCCCCCCCCCCCC>>[CH2:12]=[CH:17][CH2:16][N:15]1[C@@H:18]2[CH2:19][C:20]3[CH:21]=[CH:22][C:23]([OH:78])=[C:32]4[O:34][C@H:26]5[C:27]([CH2:39][CH2:40][C@:35]2([OH:37])[C@:30]5([C:31]=34)[CH2:13][CH2:14]1)=[O:29].[CH3:1][CH2:2][C:3]([N:5]([CH:12]1[CH2:13][CH2:14][N:15]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:16][CH2:17]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4]

Participants

Reactant 2

HCID 11177Magnesium Stearate

HCID 13810Fentanyl Citrate

Product 1

HCID 86641843Naloxone Fentanyl

Procedure

Fentanyl citrate was added to the carrier material in amounts corresponding to a batch size of 300 tablets. Mixing was carried out under the same conditions as those described in Example 1. Croscarmellose sodium and silicified microcrystalline cellulose, and then magnesium stearate, were added and admixed under the same conditions as those described in Example 1.

Workup

additionMixing

Sources & evidence

ORD record: ord-4dd9c14257d746a4973130c2e6fabeb5
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08821914B2

Linked notes

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