Magnesium Stearate

HCID 11177CAS 557-04-0

Basic information

Standard SMILES
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
InChIKey
HQKMJHAJHXVSDF-UHFFFAOYSA-L
Molecular formula
C36H70MgO4
Average molar mass
591.2 g/mol
Monoisotopic mass
590.5124524

Names & identifiers

Preferred name
Magnesium Stearate
IUPAC
magnesium bis(octadecanoate)
English name
Magnesium stearate
Molecular formula
C36H70MgO4
Molecular weight
591.24

Names & synonyms

MAGNESIUM STEARATE557-04-0Magnesium distearateMagnesium octadecanoateDibasic magnesium stearateOctadecanoic acid, magnesium saltSynpro 90Stearic acid, magnesium saltPetrac MG 20NFMagnesium stearate gSynpro Magnesium Stearate 90Magnesii stearas
Show more names
stearatedemagnesiumMagnesium Stearate BpMAGNESIUM STEARATE N.F.Magnesium Stearate Veg. NFC4d-ADolomolAnti-C4d-Apetracmg20nfnesium stearate
NP 1500SM 1000Octadecanoic acid, magnesium salt (2:1)CHEBI:925470097M6I30DTXSID2027208DAYCLINGRefChem:5973

Database identifiers

CAS
557-04-0
PubChem CID
11177
DTXSID
DTXSID2027208
ChEMBL
CHEMBL2106633
ChEBI
CHEBI:9254
UNII
70097M6I30
EC Number
209-150-3
Nikkaji
J43.178H

Properties

Computed structural properties

Topological polar surface area
80.3 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
4
Rotatable bonds
30
Heavy atoms
41

Physicochemical properties

Melting point
200 °C · 200 °C (lit.)
Density
1.028 g/cm3 · 1.028g/cm3
storage temp.
Inert atmosphere,Room Temperature
solubility
alcohol: insoluble
form
Fine Powder
color
White

Safety & regulation

Safety data

PPE
dust mask type N95 (US), Eyeshields, Gloves
wgk
-
tsca
TSCA listed
rtecs
WI4390000
hs_code
29157030
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg

Chemistry & industry

Applications · 6 items

UsesMagnesium stearate has been widely used for many decades in the food industry as an emulsifier, binder and thickener, as well as an anticaking, lubricant, release, and antifoaming agent. It is present in many food supplements, confectionery, chewing gum, herbs and spices, and baking ingredients. Magnesium stearate is also commonly used as an inactive ingredient in the production of pharmaceutical tablets, capsules and powders. The main reason for its good lubricating properties is its hydrophobic nature and an ability to reduce friction between tablets and die wall during the ejection process. Magnesium stearate can be regarded as being non-toxic, the United States, Germany and Japan allow it to be applied to products being contact with food. However, it doesn’t have wide application to be applied as PVC heat stabilizers. In China and some other countries Pharmacopoeia, there are always records of this specie. The pharmacopeia has also made provisions on the magnesium content, moisture, heavy metals, iron, sulfate and chloride content.

DescriptionMagnesium stearate, also called octa decanoic acid, magnesium salt, is a white substance, powder which becomes solid at room temperature. It has the chemical formula Mg(C18H35O2)2. It is a salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+). Magnesium stearate melts at about 120 °C, is not soluble in water, and is generally considered safe for human consumption at levels below 2500 mg/kg per day.In 1979, the FDA's Subcommittee on GRAS (generally recognized as safe) Substances (SCOGS) reported, "There is no evidence in the available information on ... magnesium stearate ... that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current and in the manner now practiced, or which might reasonably be expected in the future.".

Useswidely used in the fields of the plastic, mold-releasing agent for tablets (need meeting the medicine criterion), emulsifying agents of cosmetics. It also can conjugate with Ca Soap as stabilizer of PVC.

UsesMagnesium Stearate is the magnesium salt of stearic acid which functions as a lubricant, binder, emulsifier, and anticaking agent. it is a white powder that is insoluble in water. it is used as a lubricant or die release in tableting pressed candies and is also used in sugar- less gum and mints.

UsesMagnesium stearate is often used as a anti-adherent in the manufacture of medical tablets, capsules and powders. In this regard, the substance is also useful, because it has lubricating properties, preventing ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets; magnesium stearate is the most commonly used lubricant for tablets. Studies have shown that magnesium stearate may affect the release time of the active ingredients in tablets, etc., but not that it reduces the overall bioavailability of those ingredients. As a food additive or pharmaceutical excipient, its E number is E470b. Magnesium stearate is also used to bind sugar in hard candies like mints, and is a common ingredient in baby formulas. In pure powder form, the substance can be a dust explosion hazard, although this issue is effectively insignificant beyond the manufacturing plants using it. Magnesium stearate is manufactured from both animal and vegetable oils. Some nutritional supplements specify that the magnesium stearate used is sourced from vegetables. Magnesium stearate is a major component of "bathtub rings." When produced by soap and hard water, magnesium stearate and calcium stearate both form a white solid insoluble in water, and are collectively known as "soap scum.".

General DescriptionMagnesium stearate (Mg-St) is the magnesium salt of stearic acid. Its anhydrate, dihydrate and trihydrate forms have been prepared. The tabletting of the blends of magnesium stearate and lactose granules has been described. The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined. Mg-St is widely used lubricant in pharmaceutical industry. It also plays a role in delaying the process of dissolution. Its detection in tablets by laser-induced breakdown spectroscopy has been proposed.

Preparation methods

PreparationMagnesium stearate is created by the reaction of sodium stearate with magnesium sulfate.

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
山东旭晨化工科技有限公司0533-15715337262 15715337262 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

Additional notes

DefinitionMg(C18H35O2)2 or with one H2O. Technical grade contains small amounts of the oleate and 7% magnesium oxide, MgO.

Related reactions

19 records

Linked notes

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