Lithium ion → 1-(4-{4-[(3-pyrrolidin-1-ylpropyl)thio]phenyl}tetrahydro-2H-pyran-4-yl)methanamine

Reaction equation

[Al+3:25].[H-:24].[H-:27].[H-:28].[H-:29].[Li+:26].[N:1]1([CH2:6][CH2:7][CH2:8][S:9][c:10]2[cH:11][cH:12][c:13]([C:16]3([C:22]#[N:23])[CH2:17][CH2:18][O:19][CH2:20][CH2:21]3)[cH:14][cH:15]2)[CH2:2][CH2:3][CH2:4][CH2:5]1>>[N:1]1([CH2:6][CH2:7][CH2:8][S:9][c:10]2[cH:11][cH:12][c:13]([C:16]3([CH2:22][NH2:23])[CH2:17][CH2:18][O:19][CH2:20][CH2:21]3)[cH:14][cH:15]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

Reactant 4

HCID 28486Lithium ion

HCID 104727Aluminum Cation

HCID 166653Hydride4×

HCID 598374854-{4-[(3-pyrrolidin-1-ylpropyl)thio]phenyl}tetrahydro-2H-pyran-4-carbonitrile

Product 1

HCID 685766791-(4-{4-[(3-pyrrolidin-1-ylpropyl)thio]phenyl}tetrahydro-2H-pyran-4-yl)methanamine

Sources & evidence

ORD record: ord-2cc90ec8be9b4fc29b47323e0930037e
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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