Hydrochloric Acid → 4-Methoxy-6-(piperazin-1-yl)pyrimidine hydrochloride
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[CH3:21][O:20][C:18]1[CH:19]=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[N:15]=[CH:16][N:17]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
8.61 g 4-(6-Methoxy-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester were stirred in 4 mol/L HCl solution in dioxane for 1 h. The precipitates was filtered, washed with dioxane and dried to yield 5.17 g of the desired compound.
Workup
- filtrationThe precipitates was filtered
- washwashed with dioxane
- customdried
Sources & evidence
- ORD record
- ord-e87ea1655a2c48908d1f21d8f951fece
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08822464B2
Reaction notes
Loading…