Butanal → 3-[1-(1H-indol-3-yl)butyl]-1H-indole

HRID 6940

Reaction equation

HRID 6940 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[CH:10](=O)[CH2:11][CH2:12][CH3:13]>CO.O>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]([C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)[CH2:11][CH2:12][CH3:13])=[CH:2]1

Participants

5

Reactant 2

HCID 261ButanalHCID 798Indole

Product 1

HCID 102661333-[1-(1H-indol-3-yl)butyl]-1H-indole

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

282 mg of indole (2.4 mmol) were dissolved in 10 ml of CH3OH and 5 ml of H2O; 72 mg (1 mmol) of butyraldehyde and 240 mg of dysprosium triflate-(CF3SO3)3Dy-(0.393 mmol) were added.

Sources & evidence

ORD record
ord-a7069c89951542c6aac014e0ba0b4104
Source dataset
uspto-grants-2006_08
Patent number
US07084166B2

Linked notes

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