4-Methoxy-2-methylbenzoic acid → (S)-7-[4-(4-methoxy-2-methyl-benzoylamino)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester

HRID 69441

Reaction equation

HRID 69441 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C@:10]2([CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=3)[CH2:13]2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:24][O:25][C:26]1[CH:34]=[CH:33][C:29]([C:30](O)=[O:31])=[C:28]([CH3:35])[CH:27]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C@:10]2([CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:30](=[O:31])[C:29]4[CH:33]=[CH:34][C:26]([O:25][CH3:24])=[CH:27][C:28]=4[CH3:35])=[CH:19][CH:18]=3)[CH2:13]2)[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 5972164-Methoxy-2-methylbenzoic acidHCID 68994472(S)-7-(4-amino-phenyl)-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester

Product 1

HCID 68990294(S)-7-[4-(4-methoxy-2-methyl-benzoylamino)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester

Procedure

According to Method P, (S)-7-(4-amino-phenyl)-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester was reacted with 4-methoxy-2-methyl-benzoic acid. In this way the product was obtained with molecular weight 465.60 (C27H35N3O4); MS (ESI): 466 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 465.60 (C27H35N3O4)

Sources & evidence

ORD record
ord-4411a7611f2e413ca00db0c0a4c00637
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Linked notes

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