N-Formylmorpholine → 6-Benzyloxy-2-((R)-4-[1,3']bipyrrolidinyl-1'-yl-3-methoxy-phenyl)-2H-isoquinolin-1-one

HRID 69450

Reaction equation

HRID 69450 reaction equation
[CH2:1]([O:8][C:9]1[CH:35]=[CH:34][C:12]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:26][CH2:25][C@@H:24]([N:27]4[CH2:31][CH2:30][CH2:29][CH2:28]4)[CH2:23]3)=[C:18]([O:32][CH3:33])[CH:17]=2)=[O:14])=[C:11]([CH3:36])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:37](N1CCOCC1)=O>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:12](=[CH:34][CH:35]=1)[C:13](=[O:14])[N:15]([C:16]1[CH:21]=[CH:20][C:19]([N:22]3[CH2:26][CH2:25][C@@H:24]([N:27]4[CH2:31][CH2:30][CH2:29][CH2:28]4)[CH2:23]3)=[C:18]([O:32][CH3:33])[CH:17]=1)[CH:37]=[CH:36]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 20417N-FormylmorpholineHCID 689888534-benzyloxy-N-((R)-4-[1,3']bipyrrolidinyl-1'-yl-3-methoxy-phenyl)-2-methyl-benzamide

Product 1

HCID 689900956-Benzyloxy-2-((R)-4-[1,3']bipyrrolidinyl-1'-yl-3-methoxy-phenyl)-2H-isoquinolin-1-one

Procedure

According to Method Q, 4-benzyloxy-N—((R)-4-[1,3′]bipyrrolidinyl-1′-yl-3-methoxy-phenyl)-2-methyl-benzamide was reacted with N-formylmorpholine. In this way the product was obtained with molecular weight 495.63 (C31H33N3O3); MS (ESI): 496 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 495.63 (C31H33N3O3)

Sources & evidence

ORD record
ord-c03e5af6b18b47b098c8f2fbfa3a8f17
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Linked notes

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