HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Chloro-3'-nitroacetophenone → Tert-butyl 1-(4-acetyl-2-nitrophenyl)piperidin-4-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Chloro-3'-nitroacetophenone | HCID 79596 | — |
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Product | Tert-butyl 1-(4-acetyl-2-nitrophenyl)piperidin-4-ylcarbamate | HCID 51119762 | 95% |
Reaction Steps
Method 1 was followed using 4-chloro-3-nitroacetophenone (1.0 eq), 4-(N-Boc-amino) piperidine (1.2 eq), and TEA (2.0 eq) at 55° C. overnight yielding tert-butyl 1-(4-acetyl-2-nitrophenyl)piperidin-4-ylcarbamate (95%). LCMS (m/z): 364.1 (MH+); LC Rt=2.99 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-9badc0c721d24566a7bce657b4531b3d |
| Source note | uspto-grants-2014_09 |