Ethylenediamine → N'-(2-chlorophenyl)ethane-1,2-diamine
Reaction equation
Clc1ccccc1Br.NCCN>CC(=O)O.CC(=O)O.CC(C)(C)[O-].Cc1ccc(P(c2ccc(C)cc2)c2ccc(C)cc2)cc1.Cc1ccccc1.[Na+].[Pd]>NCCNc1ccccc1ClParticipants
7
Reactant 2
Product 1
Reagents, catalysts & solvents 4
Conditions
- Temperature
- 140 °C
Procedure
Ref: R2239 To a mixture of 1-bromo-2-chlorobenzene (0.824 g, 4.30 mmol), tri-p- tolylphosphine (0.262 g, 0.86 mmol), sodium 2-methylpropan-2-olate (0.414 g, 4.30 mmol), diacetoxypalladium (0.097 g, 0.43 mmol) in toluene (4 mL) was added ethane-1,2-diamine (1.293 g, 21.52 mmol). The mixture was heated with microwave at 140 °C for 1 h. No product was formed.
Sources & evidence
- ORD record
- ord-5911a740f60145b0bc355f2a886b772f
- Source dataset
- 750 AstraZeneca ELN dataset
- Original link
- View source
Reaction notes
Loading…