4-hydroxy-3-methoxy-N-[3-(2-phenylethynyl)phenyl]-phenylacetamide → 4-hydroxy-3-methoxy-N-[2-(2-phenylethyl)phenyl]phenylacetamide

HRID 7078

Reaction equation

HRID 7078 reaction equation
OC1C=CC(CC(NC2C=CC=C(C#CC3C=CC=CC=3)C=2)=O)=CC=1OC.[OH:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][C:36]([NH:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[C:45]#[C:46][C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)=[O:37])=[CH:31][C:30]=1[O:53][CH3:54]>>[OH:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][C:36]([NH:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[CH2:45][CH2:46][C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)=[O:37])=[CH:31][C:30]=1[O:53][CH3:54]

Participants

3

Reactant 2

HCID 220196124-hydroxy-3-methoxy-N-[3-(2-phenylethynyl)phenyl]-phenylacetamide2×HCID 220196734-hydroxy-3-methoxy-N-[2-(2-phenylethynyl)phenyl]-phenylacetamide2×

Product 1

HCID 220196174-hydroxy-3-methoxy-N-[2-(2-phenylethyl)phenyl]phenylacetamide

Procedure

Instead of 4-hydroxy-3-methoxy-N-[3-(2-phenylethynyl)phenyl]-phenylacetamide (the compound of Example 36) in Example 54, 4-hydroxy-3-methoxy-N-[2-(2-phenylethynyl)phenyl]phenylacetamide (the compound of Example 107) is treated in a similar manner to Example 54 to give the desired compound.

Sources & evidence

ORD record
ord-8b82934688844b438738b1ec34f7bba1
Source dataset
uspto-grants-2006_08
Patent number
US07084176B2

Linked notes

Loading…