Oxalyl chloride → Dimethyl-1,3-oxazole-5-carbonyl chloride

HRID 708787

Reaction equation

HRID 708787 reaction equation
[CH3:1][C:2]1[O:3][C:4]([C:8]([OH:10])=O)=[C:5]([CH3:7])[N:6]=1.C(Cl)(=O)C([Cl:14])=O>C(Cl)Cl>[CH3:1][C:2]1[O:3][C:4]([C:8]([Cl:14])=[O:10])=[C:5]([CH3:7])[N:6]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 1132979Dimethyl-1,3-oxazole-5-carboxylic acid

Product 1

HCID 12336332Dimethyl-1,3-oxazole-5-carbonyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirring solution of 2,4-dimethyl-oxazole-5-carboxylic acid (30 mg) in DCM (2.0 mL), oxalyl chloride (3.0 eq) was added at room temperature. The reaction mixture was stirred for 30 minutes. Solvents were evaporated and dried under vacuo to afford 2,4-dimethyl-oxazole-5-carbonyl chloride.

Workup

  1. customSolvents were evaporated
  2. customdried under vacuo

Sources & evidence

ORD record
ord-051aa11aea3d49acb73551ed03209563
Source dataset
uspto-grants-2015_11
Patent number
US09175003B2

Linked notes

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