Benzonatate → Benzonatate calcium silicate

HRID 709002

Reaction equation

[Si:1]([O-:5])([O-:4])([O-:3])[O-:2].[Ca+2:6].[Ca+2].[CH3:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]([O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][O:30][CH2:31][CH2:32][O:33][CH2:34][CH2:35][O:36][CH2:37][CH2:38][O:39][CH2:40][CH2:41][O:42][CH2:43][CH2:44][O:45][CH2:46][CH2:47][O:48][CH3:49])=[O:20])=[CH:17][CH:18]=1>>[CH3:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][O:30][CH2:31][CH2:32][O:33][CH2:34][CH2:35][O:36][CH2:37][CH2:38][O:39][CH2:40][CH2:41][O:42][CH2:43][CH2:44][O:45][CH2:46][CH2:47][O:48][CH3:49])=[O:20])=[CH:15][CH:14]=1.[Si:1]([O-:5])([O-:4])([O-:3])[O-:2].[Ca+2:6].[Ca+2:6]

Participants

Reactant 2

HCID 7699Benzonatate

HCID 14941Dicalcium silicate

Product 1

HCID 131733891Benzonatate calcium silicate

Procedure

Using the ingredients in the immediately preceding table, calcium silicate was mixed at slow speed in a high shear granulator (Impeller: 250 rpm and Chopper: 3200 rpm). Benzonatate was added to it at slow speed (Impeller: 250 rpm and Chopper: 3200 rpm) at a rate of approximately 7 g/minute. The benzonatate-calcium silicate adsorbate granules formed were passed through 425 micron screen. Using the assay described herein, the amount of benzonatate was determined to be 60.66 wt % benzonatate based on the total weight of the adsorbate.

Workup

additionwas mixed at slow speed in a high shear granulator (Impeller: 250 rpm and Chopper: 3200 rpm)

Sources & evidence

ORD record: ord-8d80426bed3847c8b4b3da516b13fb64
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09180104B2

Linked notes

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