Hydroxyamine hydrochloride → 2-(3,4-Dimethoxyphenoxy)-N'-hydroxyacetoimidamide
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[O:6][CH2:7][C:8]#[N:9].Cl.[OH:16][NH2:17]>CO.O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[O:6][CH2:7][C:8](=[N:17][OH:16])[NH2:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
To a solution of 2-(3,4-dimethoxyphenoxy)acetonitrile (3.8 g) in MeOH—H2O (1:1), hydroxyamine hydrochloride was added and the mixture was stirred at 100° C. for 3 hours. After distilling off the solvent under reduced pressure, the residue was recovered by filtration and washed with water and hexane to give a crude form of the titled compound (4.9 g).
Workup
- distillationAfter distilling off the solvent under reduced pressure
- filtrationthe residue was recovered by filtration
- washwashed with water and hexane
Sources & evidence
- ORD record
- ord-9ca000f3a7e144bdbd9b052e1308891e
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09181229B2
Reaction notes
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