Phosphorus oxychloride → HCID 178478072, compound

HRID 710527Notes

Reaction equation

HRID 710527 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11](O)=O.[N:14]1[C:18]2[CH:19]=[CH:20][C:21]([C:23]([NH:25][NH2:26])=O)=[CH:22][C:17]=2[NH:16][CH:15]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:36])=CC=1.O=P(Cl)(Cl)Cl>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11]1[S:36][C:23]([C:21]2[CH:20]=[CH:19][C:18]3[NH:14][CH:15]=[N:16][C:17]=3[CH:22]=2)=[N:25][N:26]=1

Participants

5

Reactant 4

HCID 24813Phosphorus oxychlorideHCID 87949Lawesson's reagentHCID 27409153-(2,4-Dichlorophenyl)propanoic acidHCID 166371191H-benzimidazole-5-carbohydrazide

Product 1

HCID 178478072HCID 178478072, compound

Procedure

The compound was synthesized starting from 3-(2,4-dichlorophenyl)propionic acid (220 mg; 1 mmol), benzimidazol-5-carbohydrazide (176 mg; 1 mmol), Lawesson's reagent (606 mg; 1.5 mmol) and POCl3 (0.137 ml; 1.5 mmol) as described in method 3; yield: 0.016 g (4.3%);

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-54b7f1cd933f44a5ace207c066cc7149
Source dataset
uspto-grants-2015_11
Patent number
US09181233B2

Reaction notes

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