(2-Methoxypyridin-4-yl)methanamine → 4-(Aminomethyl)pyridin-2(1H)-one

HRID 711263

Reaction equation

HRID 711263 reaction equation
C[O:2][C:3]1[CH:8]=[C:7]([CH2:9][NH2:10])[CH:6]=[CH:5][N:4]=1>Cl>[NH2:10][CH2:9][C:7]1[CH:6]=[CH:5][NH:4][C:3](=[O:2])[CH:8]=1

Participants

3

Reactant 1

HCID 16227983(2-Methoxypyridin-4-yl)methanamine

Product 1

HCID 150793014-(Aminomethyl)pyridin-2(1H)-one

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The starting material (2-methoxypyridin-4-yl)methanamine 56-2 in 3N HCl was refluxed at 110° C. for 12 hours. The reaction was taken to dryness by rotary evaporation to give crude 4-(aminomethyl)pyridin-2(1H)-one 56-3.

Workup

  1. customThe reaction was taken to dryness by rotary evaporation

Sources & evidence

ORD record
ord-0a0113fcf18d4c1b932891df2d2f6d59
Source dataset
uspto-grants-2015_11
Patent number
US09181235B2

Linked notes

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