2-Amino-2-methyl-1-propanol → 1-(1-Hydroxy-2-methylpropan-2-yl)-3-[4-(trifluoromethoxy)phenyl]urea
Reaction equation
CC1(C)CCN(C2C=CC(SC(F)(F)F)=CC=2)C(=O)N1CC1C2C(=NC=CC=2)NC=1.[NH2:31][C:32]([CH3:36])([CH3:35])[CH2:33][OH:34].[F:37][C:38]([F:50])([F:49])[O:39][C:40]1[CH:45]=[CH:44][C:43]([N:46]=[C:47]=[O:48])=[CH:42][CH:41]=1>>[OH:34][CH2:33][C:32]([NH:31][C:47]([NH:46][C:43]1[CH:44]=[CH:45][C:40]([O:39][C:38]([F:37])([F:49])[F:50])=[CH:41][CH:42]=1)=[O:48])([CH3:36])[CH3:35]Participants
4
Reactant 3
Product 1
Procedure
1-(1-hydroxy-2-methylpropan-2-yl)-3-[4-(trifluoromethoxy)phenyl]urea was prepared similar to compound 5, but the following reagents were used: 2-amino-2-methyl-1-propanol and 4-(trifluoromethoxy)phenylisocyanate. LCMS [M+H]+=293.1.