Hydrazine hydrate (1:1) → 7-Bromo-2-hydrazinylquinoxaline

HRID 711364

Reaction equation

HRID 711364 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](Cl)=[N:9]2)=[CH:4][CH:3]=1.O.[NH2:14][NH2:15]>C(O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8]([NH:14][NH2:15])=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 49132537-Bromo-2-chloroquinoxaline

Product 1

HCID 52002657-Bromo-2-hydrazinylquinoxalineYield 87%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
78 °C

Procedure

To the solution of 7-bromo-2-chloroquinoxaline (2 g, 8.2 mmol) in ethanol (20 mL) was added hydrazine hydrate (85%, 4.5 mL, 32.8 mmol). The mixture was heated to 78° C. for 2 h. After cooling to r.t., the precipitate was collected by filtration to afford 7-bromo-2-hydrazinylquinoxaline as white solid in 87% yield (1.7 g).

Workup

  1. temperatureAfter cooling to r.t.
  2. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-08c8fad82e5d4612abccac1ebd254385
Source dataset
uspto-grants-2015_11
Patent number
US09181264B2

Linked notes

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