Butyryl chloride → N-(1-hydroxy-2-methylpropan-2-yl)butyramide

Reaction equation

[NH2:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].[C:7](Cl)(=[O:11])[CH2:8][CH2:9][CH3:10]>>[OH:4][CH2:3][C:2]([NH:1][C:7](=[O:11])[CH2:8][CH2:9][CH3:10])([CH3:6])[CH3:5]

Participants

Reactant 2

HCID 8855Butyryl chloride

HCID 118072-Amino-2-methyl-1-propanol

Product 1

HCID 12497727N-(1-hydroxy-2-methylpropan-2-yl)butyramideYield 32%

Procedure

Prepared according to the literature (Boyd, R. N.; Hansen, R. H. J. Am. Chem. Soc. 1953, 75, 5896) from 2-amino-2-methylpropan-1-ol and butyryl chloride in 32% yield. MS 160 (MH+).

Workup

customPrepared

Sources & evidence

ORD record: ord-b93f49ab64aa499cacb28e8e6ed70ef5
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09181276B2

Reaction notes

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