4-Piperidinecarboxylicacid, 4-hydroxy-1-(phenylmethyl)- → 4-hydroxypiperidine-4-carboxylic Acid
Reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]([OH:17])([C:14]([OH:16])=[O:15])[CH2:10][CH2:9]1)C1C=CC=CC=1>CCO.[OH-].[Pd+2].[OH-]>[OH:17][C:11]1([C:14]([OH:16])=[O:15])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To the solution of 1-benzyl-4-hydroxypiperidine-4-carboxylic acid (1.0 g, 4.25 mmol) in EtOH (15.0 mL) was added palladium hydroxide (0.40 g, 40% w/w) at rt and the mixture stirred at rt for 20 h under H2 atmosphere. After completion of reaction (by TLC) the mixture was passed through celite and the solvent evaporated. The crude (0.70 g) residue was carried forward for next step without further purification. MS: 145.99 [M+H]+.
Workup
- customAfter completion of reaction (by TLC) the mixture
- customthe solvent evaporated
- customThe crude (0.70 g) residue was carried forward for next step without further purification
Sources & evidence
- ORD record
- ord-a7b19ad20be74b3bba2796b50d0ee09b
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09181234B2
Reaction notes
Loading…