Benzoylhydrazine → N-(4-(2-(2-phenylacetyl)hydrazinecarbonyl)pyridin-2-yl)benzamide

HRID 714287

Reaction equation

HRID 714287 reaction equation
C(NN)(=O)C1C=CC=CC=1.[C:11]1([CH2:17][C:18]([NH:20][NH2:21])=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[C:22]([NH:30][C:31]1[CH:32]=[C:33]([CH:37]=[CH:38][N:39]=1)[C:34](O)=[O:35])(=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:11]1([CH2:17][C:18]([NH:20][NH:21][C:34]([C:33]2[CH:37]=[CH:38][N:39]=[C:31]([NH:30][C:22](=[O:29])[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:32]=2)=[O:35])=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 3

HCID 11955BenzoylhydrazineHCID 70301Benzeneacetic acid, hydrazideHCID 64393851HCID 64393851, compound

Product 1

HCID 67153966N-(4-(2-(2-phenylacetyl)hydrazinecarbonyl)pyridin-2-yl)benzamideYield 65%

Procedure

Following the procedure as described in Preparation 13, making variations as required to replace benzohydrazide with 2-phenylacetohydrazide to react with 2-benzamidoisonicotinic acid, N-(4-(2-(2-phenylacetyl)hydrazinecarbonyl)pyridin-2-yl)benzamide was obtained in 65% yield: MS (ES+) m/z 374.9 (M+1).

Workup

  1. customas described in Preparation 13

Sources & evidence

ORD record
ord-041b11ff412e435fbd512076e40afaa5
Source dataset
uspto-grants-2015_11
Patent number
US09187426B2

Linked notes

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