Trichloromethanethiol → 5-Chloro-3-cyclohexyl-1,2,4-thiadiazole
Reaction equation
[CH:1]1([C:7](=[NH:9])[NH2:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CCN(C(C)C)C(C)C.[Cl:19][C:20]([SH:23])(Cl)Cl>C(Cl)Cl>[Cl:19][C:20]1[S:23][N:8]=[C:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[N:9]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 2.5 °C
Procedure
Cyclohexanecarboximidamide (100 mg, 792 μmol) and DIPEA (512 mg, 3.96 mmol) in 10 mL DCM at 0-5° C. were treated with perchloromethyl mercaptan (147 mg, 792 μmol) in 5 mL DCM and stirred for 1 hr at 0-5° C. The mixture was concentrated in vacuo to give a brown solid which was used with out further purification in the subsequent step.
Workup
- concentrationThe mixture was concentrated in vacuo
- customto give a brown solid which
- customwas used with out further purification in the subsequent step
Sources & evidence
- ORD record
- ord-10a225bb09934310b118e4aec0f41614
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09187440B2
Reaction notes
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