1,1,2,2-Tetrafluoro-3-iodopropane → HCID 89874132, compound

HRID 715451

Reaction equation

HRID 715451 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([OH:8])=[C:4]([CH3:9])[CH:3]=1.[F:10][CH:11]([F:17])[C:12]([F:16])([F:15])[CH2:13]I>>[Cl:1][C:2]1[CH:3]=[C:4]([CH3:9])[C:5]([O:8][CH2:13][C:12]([F:16])([F:15])[CH:11]([F:17])[F:10])=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 5428611,1,2,2-Tetrafluoro-3-iodopropaneHCID 712995492-Chloro-5-hydroxy-4-methylpyridine

Product 1

HCID 89874132HCID 89874132, compoundYield 89%

Procedure

The title compound is prepared in 89% yield (7.97 g, pale yellow solid) from 6-chloro-4-methylpyridin-3-ol (5.00 g, 34.8 mmol) and 1,1,2,2-tetrafluoro-3-iodopropane (16.9 g, 69.7 mmol) in a similar manner to Step-1 of Amine-49.

Sources & evidence

ORD record
ord-899879fb78c84da8a2cee24eb07f6556
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Linked notes

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