Hydrochloric Acid → 1-Benzyl-3-methylpyrrolidin-3-amine dihydrochloride

HRID 72117

Reaction equation

HRID 72117 reaction equation
[CH2:1]([N:8]1[CH2:12][CH2:11][C:10]([NH:14]C(=O)C)([CH3:13])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:18]>>[ClH:18].[ClH:18].[CH2:1]([N:8]1[CH2:12][CH2:11][C:10]([CH3:13])([NH2:14])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 13787481N-(1-benzyl-3-methylpyrrolidin-3-yl)acetamide

Product 1

HCID 668848101-Benzyl-3-methylpyrrolidin-3-amine dihydrochloride

Procedure

A mixture of N-(1-benzyl-3-methylpyrrolidin-3-yl)acetamide (4.01 g, 17.2 mmol) and conc HCl (50 mL) was heated at reflux for 2 d. The mixture was evaporated under reduced pressure to leave 1-benzyl-3-methylpyrrolidin-3-amine dihydrochloride salt as a brown tar.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2 d
  3. customThe mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-310dbf237d6e40efa44cc49107bad530
Source dataset
uspto-grants-2014_09
Patent number
US08828985B2

Linked notes

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