3-Aminobenzoic Acid → 2-(3-Aminophenyl)-5-phenylbenzoxazole

HRID 722476

Reaction equation

HRID 722476 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[OH:14].[NH2:15][C:16]1[CH:17]=[C:18]([CH:22]=[CH:23][CH:24]=1)[C:19](O)=O>>[NH2:15][C:16]1[CH:17]=[C:18]([C:19]2[O:14][C:3]3[CH:4]=[CH:5][C:6]([C:8]4[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=4)=[CH:7][C:2]=3[N:1]=2)[CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 74193-Aminobenzoic AcidHCID 145622-Amino-4-phenylphenol

Product 1

HCID 104692292-(3-Aminophenyl)-5-phenylbenzoxazole

Procedure

Prepared by the method of Example 1a), from 2-amino-4-phenylphenol (674 mg, 3.6 mmol) and 3-aminobenzoic acid (500 mg, 3.6 mmol) the subtitle compound was obtained, 84 mg (8%). 1H NMR (CDCl3) δ 7.97(bs, 1H), 7.70–7.57(m, 5H), 7.49(t, 1H), 7.45–7.35(m, 2H), 6.96(d, J=7.9 Hz, 1H). MS 287 m/z (M+H)+.

Sources & evidence

ORD record
ord-1874b2c2cc2440eca82c6db87907196b
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Linked notes

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