p-Toluenesulfonic acid monohydrate → HCID 21884302, compound

Reaction equation

O[C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=[O:21])[C:11]1[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:12]=1[F:20].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N+:17]([C:15]1[CH:16]=[C:11]([C:10]2[O:21][C:2]3[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=3[N:9]=2)[C:12]([F:20])=[CH:13][CH:14]=1)([O-:19])=[O:18]

Participants

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrate

HCID 21884435HCID 21884435, compound

Product 1

HCID 21884302HCID 21884302, compound

Procedure

Prepared by the method of Example 15b), from N-(2-hydroxy-4-methylphenyl)-2-fluoro-5-nitrobenzamide (300 mg, 2.8 mmol) and p-toluenesulfonic acid monohydrate (1.17 g, 6.16 mmol) the subtitle compound was obtained (403 mg, 53%). MS m/z 273.2 (M+H)+.

Sources & evidence

ORD record: ord-0850d52ba2e642eaa7abba3fb2f4ec81
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07138425B2

Reaction notes

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