Phosphorus tribromide → 4-Bromo-6,8-difluoroquinoline
Reaction equation
O[C:2]1[C:11]2[C:6](=[C:7]([F:13])[CH:8]=[C:9]([F:12])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.P(Br)(Br)[Br:15]>CN(C)C=O>[Br:15][C:2]1[C:11]2[C:6](=[C:7]([F:13])[CH:8]=[C:9]([F:12])[CH:10]=2)[N:5]=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
This was prepared from 4-hydroxy-6,8-difluoro-quinoline by heating with phosphorus tribromide in dimethylformamide.
Sources & evidence
- ORD record
- ord-b9f0565738b84e0caf05ac3dd3ebefed
- Source dataset
- uspto-grants-2006_11
- Patent number
- US07141564B2
Reaction notes
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