Ammonium Chloride → 6-amino-4-fluoro-3-isopropyl-1,3-benzoxazol-2(3H)-one

HRID 723935Notes

Reaction equation

HRID 723935 reaction equation
[F:1][C:2]1[C:7]2[N:8]([CH:12]([CH3:14])[CH3:13])[C:9](=[O:11])[O:10][C:6]=2[CH:5]=[C:4]([N+:15]([O-])=O)[CH:3]=1.[Cl-].[NH4+]>C(O)C.O.[Fe]>[NH2:15][C:4]1[CH:3]=[C:2]([F:1])[C:7]2[N:8]([CH:12]([CH3:14])[CH3:13])[C:9](=[O:11])[O:10][C:6]=2[CH:5]=1

Participants

6

Reactant 2

HCID 25517Ammonium ChlorideHCID 68487872HCID 68487872, compound

Product 1

HCID 684896766-amino-4-fluoro-3-isopropyl-1,3-benzoxazol-2(3H)-one

Reagents, catalysts & solvents 3

HCID 23925IronCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Prepared from 4-fluoro-3-isopropyl-6-nitro-1,3-benzoxazol-2(3H)-one (Step 1, 0.87 g, 3.64 mmol), ammonium chloride (1.95 g, 36.4 mmol) and iron powder (0.81 g, 14.6 mmol) in ethanol (30 ml) and water (15 ml) according to the method of EXAMPLE 86, Step 7 (0.77 g, 99%).

Sources & evidence

ORD record
ord-72e5a3046f50441e9d2e41abaf387a75
Source dataset
uspto-grants-2006_11
Patent number
US07141588B2

Reaction notes

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