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Bromine → HCID 10524413, compound

HRID 724933
Notes
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Reaction equation

HRID 724933 reaction equation
[Cl:1][C:2]1[C:7]([NH:8][C:9]([C:11]2[C:12]([NH:17][CH2:18][CH3:19])=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:10])=[CH:6][CH:5]=[C:4]([Cl:20])[N:3]=1.C([O-])(=O)C.[K+].[Br:26]Br>C(O)(=O)C.O>[Cl:1][C:2]1[C:7]([NH:8][C:9]([C:11]2[C:12]([NH:17][CH2:18][CH3:19])=[N:13][CH:14]=[C:15]([Br:26])[CH:16]=2)=[O:10])=[CH:6][CH:5]=[C:4]([Cl:20])[N:3]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 24408BromineHCID 517044Potassium AcetateHCID 10828808N-(2,6-Dichloro-3-pyridinyl)-2-ethylamino-3-pyridinecarboxamide

Product 1

HCID 10524413HCID 10524413, compoundYield 91.4%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolvent
HCID 962
Water
Solvent

Procedure

To a solution of N-(2,6-dichloro-3-pyridinyl)-2-ethylamino-3-pyridinecarboxamide (7.4 g, 24 mmol) and potassium acetate (2.8 g, 28 mmol) in 90 mL of acetic acid was added bromine (1.2 mL, 23 mmol). After 15 min, the reaction mixture was diluted with water and the precipitate was collected by suction filtration to give 8.2 g of the title compound, suitable for use in the next reaction.

Workup

  1. filtrationthe precipitate was collected by suction filtration

Sources & evidence

ORD record
ord-6e0dd69969e54a58bc9d14da8ee9e638
Source dataset
uspto-grants-1998_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05705499

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes