Hydroxyamine hydrochloride → alpha-Oximino-3-pyridylacetamidoxime

HRID 727362

Reaction equation

HRID 727362 reaction equation
[N:1](=[C:3]([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)[C:4]#[N:5])[OH:2].Cl.[NH2:13][OH:14].C([O-])(=O)C.[Na+]>C(O)C>[N:1](=[C:3]([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)[C:4](=[N:13][OH:14])[NH2:5])[OH:2]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 72747148alpha-Oximino-3-pyridylacetonitrile

Product 1

HCID 136341185alpha-Oximino-3-pyridylacetamidoxime

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of alpha-oximino-3-pyridylacetonitrile (41.0 g, 279 mmol), hydroxylamine hydrochloride (21.5 g, 310 mmol) and sodium acetate (50.8 g, 620 mmol) in ethanol (99.9%, 500 ml) was refluxed for 4 h. After cooling, the precipitate was collected by filtration and dried. The precipitate contained the wanted product and sodium acetate (85 g, 168%); M+ : 180.

Workup

  1. temperaturewas refluxed for 4 h
  2. temperatureAfter cooling
  3. filtrationthe precipitate was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-93b42ebca6fd49be88d542812120742c
Source dataset
uspto-grants-1998_01
Patent number
US05712297

Linked notes

Loading…