N-(2-aminoethyl)-4-(1H-imidazol-1-yl)benzamide hydrochloride → N-(2-Aminoethyl)-4-(1H-imidazol-1-yl)benzamide

HRID 728811

Reaction equation

HRID 728811 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:18])[C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)=[CH:9][CH:8]=1>O>[NH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:18])[C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)=[CH:9][CH:8]=1

Participants

3

Reactant 1

HCID 45259278N-(2-aminoethyl)-4-(1H-imidazol-1-yl)benzamide hydrochloride

Product 1

HCID 14664358N-(2-Aminoethyl)-4-(1H-imidazol-1-yl)benzamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Dissolve N-(2-aminoethyl)-4-(1H-imidazol-1-yl)benzamide hydrochloride in 50mL H2O and pour onto a column of hydroxide anion exchange resin. Flush the column with H2O and collect fractions with pH>8. Combine the basic fractions and remove the solvents in vacuo to obtain the free base.

Workup

  1. customFlush the column with H2O
  2. customcollect fractions with pH>8
  3. customremove the solvents in vacuo
  4. customto obtain the free base

Sources & evidence

ORD record
ord-b5dab3118b764e1c8e15f1d41f6b4f33
Source dataset
uspto-grants-1991_09
Patent number
US05051423

Linked notes

Loading…