Hydrochloric Acid → Azetidine, 3-(2-bromo-5-fluorophenoxy)-, hydrochloride (1:1)
Reaction equation
[Br:1][C:2]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:3]=1[O:4][CH:5]1[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1.[ClH:21]>O1CCOCC1>[ClH:21].[Br:1][C:2]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:3]=1[O:4][CH:5]1[CH2:8][NH:7][CH2:6]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To tert-butyl 3-(2-bromo-5-fluorophenoxy)azetidine-1-carboxylate (2.28 g, 6.59 mmol) in dioxane (40 mL) was added 4 M HCl in dioxane (4.49 mL, 19.8 mmol). After a period of 18 h, the white solid was filtered and washed with cold dioxane to give the title compound.
Workup
- filtrationthe white solid was filtered
- washwashed with cold dioxane
Sources & evidence
- ORD record
- ord-0c30d5f758f748ccaa44cd06639e40c0
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07582633B2
Reaction notes
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