4-(Trifluoromethyl)benzoic acid → Ethyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate

HRID 729932

Reaction equation

HRID 729932 reaction equation
O=C(C1SC=CC=1)CC(OCC)=O.S1C=CC=C1C1C=CN=C(N)N=1.C[C:27]1([CH3:35])[O:32][C:31](=[O:33])[CH2:30][C:29](=[O:34])O1.[F:36][C:37]([F:48])([F:47])[C:38]1[CH:46]=[CH:45][C:41](C(O)=O)=[CH:40][CH:39]=1>>[O:34]=[C:29]([C:41]1[CH:45]=[CH:46][C:38]([C:37]([F:48])([F:47])[F:36])=[CH:39][CH:40]=1)[CH2:30][C:31]([O:32][CH2:27][CH3:35])=[O:33]

Participants

5

Reactant 4

HCID 99664-(Trifluoromethyl)benzoic acidHCID 162492,2-Dimethyl-1,3-dioxane-4,6-dioneHCID 255159Ethyl 3-oxo-3-(thiophen-2-yl)propanoateHCID 27644074-(Thiophen-2-yl)pyrimidin-2-amine

Product 1

HCID 2760281Ethyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate

Procedure

This material is prepared by a method analogous to that described for preparation of ethyl 3-oxo-3-(2-thienyl)propanoate in preparation of 1D, starting from 2,2-dimethyl-1,3-dioxane-4,6-dione and 4-(trifluoromethyl)benzoic acid.

Workup

  1. customThis material is prepared by a method analogous to

Sources & evidence

ORD record
ord-96c3c9900e7f4930b97e02dae2d407da
Source dataset
uspto-grants-2009_09
Patent number
US07582646B2

Linked notes

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