Acetal → 1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-1-(4-methyl-cyclohexyl)-3-(5-methyl-thiazol-2-yl)-urea

HRID 731402

Reaction equation

[O:1]1[C:5]2([CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[CH3:12][CH:13]1[CH2:18][CH2:17][CH:16]([NH2:19])[CH2:15][CH2:14]1.[NH2:20][C:21]1[S:22][C:23]([CH3:26])=[CH:24][N:25]=1.C[CH2:28][O:29]C(OCC)C>>[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([N:19]([CH:16]3[CH2:17][CH2:18][CH:13]([CH3:12])[CH2:14][CH2:15]3)[C:28]([NH:20][C:21]3[S:22][C:23]([CH3:26])=[CH:24][N:25]=3)=[O:29])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1

Participants

Reactant 4

HCID 7765Acetal

HCID 806044-Methylcyclohexylamine

HCID 3517702-Amino-5-methylthiazole

HCID 5674151,4-Dioxaspiro[4.5]decan-8-one

Product 1

HCID 578839251-(1,4-Dioxa-spiro[4.5]dec-8-yl)-1-(4-methyl-cyclohexyl)-3-(5-methyl-thiazol-2-yl)-urea

Procedure

1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-1-(4-methyl-cyclohexyl)-3-(5-methyl-thiazol-2-yl)-urea was prepared in an similar manner to example 2 according to general procedures (A) and (B) using 1,4-dioxaspiro[4.5]decan-8-one, 4-methylcyclohexylamine and 2-amino-5-methylthiazole. The acetale was then hydrolysed in the following way:

Sources & evidence

ORD record: ord-e43b8a0352204a75bf3fdfcbe0c0c2b5
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582769B2

Linked notes

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