Nicardipine Hydrochloride → Nicardipine

HRID 732235

Reaction equation

O=C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.[CH3:13][C:14]1[NH:19][C:18]([CH3:20])=[C:17]([C:21]([O:23][CH2:24][CH2:25][N:26]([CH2:28][C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH3:27])=[O:22])[CH:16]([C:35]2[CH:36]=[CH:37][CH:38]=[C:39]([N+:41]([O-:43])=[O:42])[CH:40]=2)[C:15]=1[C:44]([O:46][CH3:47])=[O:45].Cl>>[CH3:13][C:14]1[NH:19][C:18]([CH3:20])=[C:17]([C:21]([O:23][CH2:24][CH2:25][N:26]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH3:27])=[O:22])[CH:16]([C:35]2[CH:36]=[CH:37][CH:38]=[C:39]([N+:41]([O-:43])=[O:42])[CH:40]=2)[C:15]=1[C:44]([O:46][CH3:47])=[O:45]

Participants

Reactant 2

HCID 41114Nicardipine Hydrochloride3×

HCID 107526(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal4×

Product 1

HCID 4474Nicardipine

Procedure

Effect of change in pH of a dextrose solution in the range 3 to 7 pH upon the addition of nicardipine hydrochloride solution was performed by first measuring the initial pH of the individual solutions; thereafter, one (1) volume of nicardipine hydrochloride solution prepared by Example-11 was mixed with nine (9) volumes of dextrose solution and the pH adjusted to a desired value in the range 3 to 7. The pH data are furnished in Table-3; the plot of difference in the pH of nicardipine hydrochloride solution before and after dilution with 5% dextrose solution versus the initial pH of dextrose solution is shown in FIG. 4. For comparison, a similar plot for the pH data reported in U.S. Pat. No. 5,164,405 for buffered and unbuffered nicardipine solution is also provided.

Workup

customThe pH data are furnished in Table-3

Sources & evidence

ORD record: ord-294947f30696487795404cba5c723015
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07585978B2

Linked notes

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