Boron tribromide → 6-(4-Methanesulfonyl-phenyl)-5-[4-(2-piperidin-1-yl-ethylamino)-phenoxy]-naphthalen-2-ol dihydrochloride

Add 4M HCl/dioxane (3 mL, 12 mmol) to a solution of the compound of Example 57 (110 mg, 0.17 mmol) in dichloromethane (3 mL) and stir the reaction for 40 minutes, then evaporate to dryness under reduced pressure. Dissolve the residue in dichloromethane (4 mL) and add boron tribromide (0.068 mL, 0.72 mmol). Stir the reaction for 3.5 hours, then add aqueous saturated sodium bicarbonate (5 mL) and allow the phases to separate. Dry the organic layer with solid magnesium sulfate and chromatograph on silica gel with dichloromethane/methanol mixtures. Evaporate the fractions containing product to dryness and redissolve in 5% methanol/dichloromethane (3 mL). Add 1M hydrogen chloride in diethyl ether (0.28 mL) then evaporate the solution under reduced pressure to give 82 mg of the title compound (77%). Mass spectrum (ion spray): m/z=517.5 (M+H).

1. customthe reaction for 40 minutes
2. customevaporate to dryness under reduced pressure
3. dissolutionDissolve the residue in dichloromethane (4 mL)
4. stirringStir
5. customthe reaction for 3.5 hours
6. customto separate
7. dry with materialDry the organic layer with solid magnesium sulfate and chromatograph on silica gel with dichloromethane/methanol mixtures
8. customEvaporate the fractions
9. additioncontaining product to dryness
10. dissolutionredissolve in 5% methanol/dichloromethane (3 mL)
11. additionAdd 1M hydrogen chloride in diethyl ether (0.28 mL)
12. customthen evaporate the solution under reduced pressure

ORD record

ord-3303630d71324a7b86f0411647e93f59

Source dataset

uspto-grants-2009_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07585977B2